Data access through the NIMH Data Archive, tutorials and documentation from the Data Integration and Resource Center, recorded talks, and the published papers to cite.
A2CPS data are maintained in the National Institute of Mental Health Data Archive (NDA). Any researcher can access them by completing a Data Access Request for the NDA permission group. In NDA, A2CPS is listed as “Data Center for Acute to Chronic Pain Biosignatures”, collection #5121.
Start early. Access requests must be reviewed and approved. Filing yours before the workshop means you can follow the hands-on segments with real data.
Built by the Data Integration and Resource Center at a2cps.github.io.
Brief tutorials for each data modality, written for researchers who know one kind of data but not another. Each kit covers how to access the relevant files and shows simple analyses in R, Python and shell, from FreeSurfer tables to brain age versus true age.
a2cps.github.io/starterkitsDocumentation for A2CPS data, including imaging processing notes such as slice packets and skull-stripping.
a2cps.github.io/docsRecorded talks and tutorials from the consortium on Vimeo. The workshop recording will be added here after the session.
vimeo.com/a2cpsData dictionaries, the original case report forms, and the HEAL common data elements used to harmonize every questionnaire.
a2cps.org · About the DataRelease timeline, versioning scheme, and release-specific documentation.
a2cps.org · Data ReleasesThe consortium home: news, directory, participant information and the researcher portal.
VisitHow participants are recruited, followed and assessed from before surgery to 12 months after.
ReadPrimary biomarker table and the list of ongoing consortium analysis projects by data type.
BrowseAll papers from the consortium, including methods papers for each data modality.
Publications pageThe primary, secondary and exploratory biomarkers A2CPS is measuring, and why.
BiomarkersQuantitative sensory testing: pressure pain thresholds, temporal summation and conditioned pain modulation.
AssessmentsGenomics, extracellular RNA, proteomics, lipidomics and metabolomics: what is assayed and where.
OmicsThe MRI protocol: structural, diffusion, resting-state and pain-evoked functional imaging.
Brain imagingClinical centers, omics centers, coordinating centers and the people behind them.
Meet the consortiumQuestions about access, collaboration or the workshop.
Get in touchTwo papers describe the program and should be cited when referring to the A2CPS protocol and biomarkers.
| Biomarker paper | Sluka KA, Wager TD, Sutherland SP, Labosky PA, Balach T, et al. Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures. PAIN, 2023. |
| Protocol paper | Berardi G, Frey-Law L, Sluka KA, Bayman EO, Coffey CS, et al. Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol. Frontiers in Medicine, 2022. |
Include the following in publications or presentations that use A2CPS data:
Full citation guidance: Accessing our Data on a2cps.org.
